New Study Links Q-actin™ to Better Sleep, Dexterity and Cognitive Wellness in Healthy Older Adults

Clinically Supported Cucumber Extract Expands Benefits Beyond Joint Health

Fairfield, CA – May 20, 2025 – IminoTech Inc. announced today new clinical research demonstrating that Q-actin™, its patented cucumber (Cucumis sativus) extract standardized to >1% ido-BR1, significantly improves sleep quality and finger dexterity in healthy older adults. The 12-week randomized and placebo-controlled study was published recently in Frontiers in Nutrition.

“Sleep disturbances are increasingly common with age and often managed with pharmaceuticals that can have undesirable side effects,” said Dr. Amanda Lloyd, lead author of the study. “Our findings suggest that Q-actin offers a gentle, effective, and natural alternative by supporting the body’s own melatonin pathways.”

Q-actin has already been clinically validated for joint comfort and mobility. This new research expands its portfolio of benefits to include sleep and cognitive wellness. Study participants experienced increases in urinary melatonin metabolites and meaningful improvements in neuromuscular function.

“We’re excited to see Q-actin demonstrate such broad potential across physical and mental wellness,” said Shil Kothari, Chief Executive Officer of IminoTech. “A natural ingredient that supports joint, sleep, and cognitive health from a single low daily dose of just 20 milligrams opens exciting formulation opportunities for supplements and functional beverages.”

Study Overview and Results

In the study, 47 healthy adults ages 50 to 78 were randomized to receive either two Q-actin gummies (providing 20 mg per day) or matched placebo gummies for 12 weeks. Participants were not selected for sleep or cognitive complaints and were asked to maintain their usual diet and activity routines. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and neuromuscular function was assessed through the Nine-Hole Peg Test. Additionally, urine samples were analyzed for levels of melatonin and its primary metabolites.

The results showed:

• Significant increases in urinary levels of melatonin, 6-sulfatoxymelatonin, and 6-hydroxymelatonin

• Improvements in subjective sleep quality

• Significant gains in finger dexterity

• No serious adverse events and a compliance rate over 99%

The authors noted that improved finger dexterity may reflect enhanced neuromuscular coordination, which is closely linked to cognitive performance in aging populations.

“The increase in melatonin and its metabolites may be mechanistically linked to Q-actin’s known anti-inflammatory effects, particularly its ability to modulate pro-inflammatory cytokines like tumor necrosis factor-alpha,” said Mr. Kothari. “Q-actin’s remarkably low daily serving size and multifunctional benefits make it an ideal standalone or combination ingredient for products that support healthy aging.”

Full study citation 

Lloyd AJ et al. “Oral supplement in healthy older adults to support physical fitness and mental wellbeing.” Frontiers in Nutrition, May 2025. doi: 10.3389/fnut.2025.1563999